IDE (clone 3H4) mouse monoclonal, anti-human, hamster

Backgroud: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been describecatalytic activity:Degradation of insulin, glucagon and other polypeptides. No action on proteins.,cofactor:Binds 1 zinc ion per subunit.,function:May play a role in the cellular processing of insulin. May be involved in intercellular peptide signaling.,PTM:The N-terminus is blocked.,similarity:Belongs to the peptidase M16 family.,subunit:Homodimer.,

Synonyms: IDE, Insulin-degrading enzyme, Abeta-degrading protease, Insulin protease, Insulinase, Insulysin

Gene Name: IDE

Gene ID: 3416

SwissProt ID: P14735

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.