IDE/Insulin Degrading Enzyme Mouse mAb

Background:
Insulin Degrading Enzyme (IDE) is a large zinc-binding protease of the M16A metalloprotease subfamily known to cleave multiple short polypeptides that vary considerably in sequence. IDE was first identified by its ability to degrade the B chain of the hormone insulin. This activity was observed over fifty years ago, though the enzyme specifically responsible for B chain cleavage was identified more recently.

Cellular localization: Cell membrane, Cytoplasm, Membrane, Secreted

Specificity: Human

Alternative Names:
Abeta degrading protease, insulin degrading enzyme, Insulin protease, Insulinase, INSULYSIN

Immunogen: Synthetic Peptide

Isotype: Mouse Monoclonal IgG1

Concentration: 1mg/ml

Recommended dilutions: WB 1:1,000, IHC 1:200

Observed band: 118kDa

GeneID: 3416

Swiss-Prot No.: P14735

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Store at -20°C. Avoid repeated freeze-thaw cycles.

NOTE: For Research Use Only