IDE Monoclonal Antibody

Background:
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.

Research Area: Cancer, Cell Biology, Cardiovascular, Metabolism, Neuroscience, Signal Transduction

Synonyms:
Abeta-degrading protease, FLJ35968, Ide, IDE, Insulin protease, Insulin-degrading enzyme, Insulinase, Insulysin, OTTHUMP00000020097

Immunogen: Synthetic Peptide

Swissprot: P14735
Observed MW: 118 kDa

Purification Method: Protein A purification

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-300, IF 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-27266/sc-130784