IDH1 (Isocitrate Dehydrogenase) Polyclonal, anti-human, mouse

Description: Defects in IDH1 are involved in the development of glioma (GLM). Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Mutations affecting Arg-132 are tissue-specific, and suggest that this residue plays a unique role in the development of high-grade gliomas. Mutations of Arg-132 to Cys, His, Leu or Ser abolish magnesium binding and abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate. Elevated levels of R(-)-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors.Localization: cytoplasmDilution: 10-100Positive Control: kidney or testis lysates, normal liverHIER: citrate pH6.0 or EDTA pH8.0Status: RUO