IDH2 polyclonal, anti-human, mouse, rat

Background:
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants.

Synonyms: D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH

Cellular Location: Mitochondrion

Immunogen:
Recombinant protein of human IDH2

Gene Symbol: IDH2

Gene ID: 3418

Swiss prot: P48735

Calculated MW: 51kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200, IF 1:20-50, IP 1:50-200, ChIP 1:20-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.