IDO polyclonal, anti-mouse

Quantity: 100 µl

Description:
IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T-cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T-cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.

Synonyms:
Indoleamine 2,3-dioxygenase, INDO

Isotype: Rabbit Polyclonal

Immunogen:
Recombinant mouse IDO.

Form: Purified, in 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.

Specificity:
Recognizes mouse IDO. Detects a band of ~45kDa by Western blot.

Reactivity: mouse

Applications: ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot

Working DIlution: Optimal conditions must be determined individually for each application.

Storage: 2-8C immediate use, or -20C (aliquoted)