IDO2 Polyclonal Antibody

Background:
INDOL1 is also known as IDO2 (indoleamine 2, 3-dioxygenase 2) and is a 407 amino acid protein that is expressed in various tissues, including liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, colon and dendritic cells. INDOL1 is selectively inhibited by D-1MT (1-methyl-d-tryptophan), which also inhibits IDO (indoleamine 2, 3-dioxygenase) and is significant because IDO expression causes suppression of T cell responses to tumors in dendritic cells. The inhibition of INDOL1 by D-1MT suggests a common function in immunomodulation. In the human INDOL1 gene, two single nucleotide polymorphisms have been detected which abolish the enzymatic function of INDOL1.

Research Area: Metabolism, Signal Transduction

Synonyms:
3-dioxygenase 2, 3-dioxygenase-like protein 1, EC 1.13.11., I23O2, IDO 2, IDO-2, Ido2, INDOL 1, Indoleamine 2, Indoleamine 2, 3 dioxygenase 2, Indoleamine 2, 3 dioxygenase like 1 protein, Indoleamine 2, 3 dioxygenase like protein 1, Indoleamine pyrrole 2, 3 dioxygenase like 1, Indoleamine pyrrole 2, 3 dioxygenase like protein 1, Indoleamine-pyrrole 2

Immunogen: Full length fusion protein

Swissprot: Q6ZQW0
Gene Accession: BC113496

Calculated MW: 45 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.