IDS Polyclonal Antibody

Background:
Iduronate 2-sulfatase (IDS) is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations causing IDS deficiency in humans result in the lysosomal storage of these glycosaminoglycans and Hunter syndrome, an X chromosome-linked disease. An internal proteolytic cleavage occurs to produce the mature IDS present in human liver shown to contain a 42 kDa polypeptide N-terminal to a 14 kDa polypeptide..

Research Area: Cell Biology

Synonyms:
Alpha L iduronate sulfate sulfatase, Alpha-L-iduronate sulfate sulfatase, AW214631, Ids, IDS, Iduronate 2 sulfatase 14 kDa chain, Iduronate 2 sulfatase 42 kDa chain, Iduronate 2 sulfatase, Iduronate 2-sulfatase 14 kDa chain, Iduronate sulfatase, Idursulfase, MPS2, RP23-29M4.1, SIDS

Immunogen: Fusion protein of human IDS

Swissprot: P22304
Gene Accession: BC006170

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.2 mg/mL
Dilution: IHC 1:50-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.