Iduronate 2 sulfatase polyclonal, anti-human

Quantity: 100 µg

Background:
IDS(Iduronate-2-sulfatase) is a sulfatase enzyme associated with Hunter syndrome. Iduronate 2-sulfatase is involved in the lysosomal degradation of the glycosaminoglycans heparan sulfate and dermatan sulfate. Wilson et al.(1991) used an IDS cDNA clone to localize the gene to Xq28, distal to the fragile X site. Faust et al.(1992) and Daniele et al.(1993) demonstrated that the homologous Ids gene in the mouse occupies the same position on the X chromosome in relation to the FMR1, F9, and GABRA3 genes. Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome. Iduronate-2-sulfatase has a strong sequence homology with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase.

Description:
Rabbit IgG polyclonal antibody for Iduronate 2-sulfatase (IDS) detection. Tested with WB, IHC-P in Human.

Synonyms:
Alpha L iduronate sulfate sulfatase antibody, Alpha-L-iduronate sulfate sulfatase antibody, AW214631 antibody, Ids antibody, IDS_HUMAN antibody, Iduronate 2 sulfatase 14 kDa chain antibody, Iduronate 2 sulfatase 42 kDa chain antibody, Iduronate 2 sulfatase antibody, Iduronate 2-sulfatase 14 kDa chain antibody, Iduronate sulfatase antibody, Idursulfase antibody, MPS2 antibody, RP23-29M4.1 antibody, SIDS antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Iduronate 2 sulfatase(430-448aa ELCREGKNLLKHFRFRDLE).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.