IFN-gamma polyclonal, anti-human

Protein Family: Cytokines

Pathway and Disease: Cancers, Folding, Sorting and Degradation, Immune System, Infectious Diseases, Metabolic Disorders, Signal Transduction

Description:
Inferferon-gamma (IFN-gamma) is produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. IFN-gamma is a potent activator of macrophages and has antiproliferative effects on transformed cells. It can potentiate the antiviral and antitumor effects of the type I interferons. In Caucasians, genetic variation in IFN-gamma is associated with the risk of aplastic anemia, a rare disease in which th ereduction of the circulating blood cells results from damage to the stem cell pool in the bone marrow. IFN-gamma (Actimmune, Genentech) is used for reducing the frequency and severity of serious infections associated with chronic granulomatous disease.

Alternate Names: Interferon gamma, IFN-gamma, Immune interferon, IFNG

Application Notes: Product Cat. No. 250707 does not react with mouse and rat IFN-gamma. E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: P01579

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human IFN-gamma.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
Pova TF et al. 2016. PLoS One. 11(12):e0168973. doi:10.1371/journal.pone.0168973. eCollection2016. PMID# 28006034.