IgA polyclonal, anti-human

Background:
Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through interchain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins. The IgA heavy chain is an α-chain, and the light chains are either κ- or λ- chains. IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces.

Alternative Name:
IGHA1, IGHA2, Hepatocellular carcinoma-associated protein TB6, Ig alpha 1 chain C region, Ig alpha 2 chain C region, IGHA, IGHA1, IGHA2, Immunoglobulin heavy constant alpha 1, Immunoglobulin heavy constant alpha 2 A2m marker, Immunoglobulin heavy constant alpha 2, PIgR, Poly-Ig receptor, polymeric immunoglobulin receptor, polymeric immunoglobulin receptor Secretory component,

Application Dilution:
WB:1:1,000
ICC:1:50-1:200
IHC:1:50-1:200
IP:1:50-1:100

Specificity: IgA polyclonal antibody detects endogenous levels of IgA protein.

Immunogen:
recombinant protein

MW: 60 kDa

Swiss-Prot: P01876(Human) P01877(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.