IGF1R polyclonal, anti-human, mouse, rat

Background:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Synonyms: IGFR, CD221, IGFIR, JTK13

Cellular Location: Cytoplasm

Immunogen:
A synthetic peptide of human IGF1R

Gene Symbol: IGF1R

Gene ID: 3480

Swiss prot: P08069

Calculated MW: 155kDa

Recommended dilution:
IHC 1:20-100

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.