IGF2 polyclonal antibody, anti-human, mouse, rat

Background:
This gene encodes a member of the insulin family of polypeptide growth factors| which are involved in development and growth. It is an imprinted gene| expressed only from the paternal allele| and epigenetic changes at this locus are associated with Wilms tumour| Beckwith-Wiedemann syndrome| rhabdomyosarcoma| and Silver-Russell syndrome. A read-through INS-IGF2 gene exists| whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Area: Signal transduction, Cancer, Developmental biology, Stem cells

Synonyms: Insulin-like growth factor II (IGF-II, Somatomedin-A) [Cleaved into: Insulin-like growth factor II, Insulin-like growth factor II Ala-25 Del, Preptin]

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year