IGFLR1 (IN101) polyclonal, anti-human

Quantity: 100 µl

Description:
Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans (IGFL1 to 4) and one in mice (mIGFL). mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. Mouse IGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 (formerly TMEM-149). Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNFR family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.

Synonyms:
IGF-like Family Receptor 1, Transmembrane Protein 149, TMEM149, U2 Small Nuclear RNA Auxiliary Factor 1-like 4

Isotype: Rabbit polyclonal

Immunogen:
Recombinant human IGFLR1 (aa 23-154).

Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.

Specificity:
Recognizes human IGFLR1. Does not recognize mouse IGFLR1.

Reactivity: human

Applications: Flow Cytometry, Western Blot

Working DIlution: Optimal conditions must be determined individually for each application.