IGHD monoclonal (N-term) (Ascites), anti-human

Background:
IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.

Other Names:
Ig delta chain C region, IGHD

Target/Specificity:
This IGHD antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 37-64 amino acids from the N-terminal region of human IGHD.

Antigen Region:
37-64

Antigen Type: Synthetic Peptide

Gene Name: IGHD {ECO:0000303|PubMed:11340299, ECO:0000303|Ref.15}
Primary Accession: P01880
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.