IKB alpha polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
NFKBIA, also called IKBA or MAD-3, is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. It is mapped to 14q13.2. NFKBIA inhibits NF-κB by masking the nuclear localization signals(NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. It moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. The effect of the nonpathogenic bacteria is specific to the SCF complex substrates CTNNB1 and NFKBIA. This may help to explain the beneficial effects of treatment of inflammatory bowel disease with nonpathogenic probiotic enteric organisms. In addition, NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-κB's proper functioning.

Description:
Rabbit IgG polyclonal antibody for NF-kappa-B inhibitor alpha (NFKBIA) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
I kappa B alpha antibody, I(Kappa)B(alpha) antibody, I-kappa-B-alpha antibody, IkappaBalpha antibody, IkB-alpha antibody, IKBA antibody, IKBA_HUMAN antibody, IKBalpha antibody, MAD 3 antibody, MAD3 antibody, Major histocompatibility complex enhancer binding protein MAD3 antibody, Major histocompatibility complex enhancer-binding protein MAD3 antibody, NF kappa B inhibitor alpha antibody, NF-kappa-B inhibitor alpha antibody, NFKBI antibody, NFKBIA antibody, Nuclear factor of kappa light chain gene enhancer in B cells antibody, Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human IKB alpha recombinant protein (Position: Q3-Q112). Human IKB alpha shares 87% and 86% amino acid (aa) sequence identity with mouse and rat IKB alpha, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.