IkB alpha Polyclonal Antibody

Background:
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Immunology, Signaling transduction

Synonyms:
I kappa B alpha, I-kappa-B-alpha, IkappaBalpha, IkB-alpha, IKBA, IKBA, IKBalpha, MAD 3, MAD3, NF kappa B inhibitor alpha, NFKBI, IKB alpha

Immunogen: Recombinant human NF-kappa-B inhibitor alpha protein

Swissprot: P25963

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 2 mg/mL
Dilution: IHC 1:50-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-847,sc-371,sc-203