IKB alpha Polyclonal Antibody

Background:
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Immunology, Signaling transduction

Synonyms:
IKBA, MAD-3, NFKBI, IKB alpha, NFKBIA, EDAID2

Immunogen: Recombinant fusion protein of human IKB alpha (NP_065390.1).

Swissprot: P25963
Gene ID: 4792

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "IHC 1:50-1:200 IF 1:20-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.