IKB beta polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
NF-kappa-B inhibitor beta, also known as IKBB or TRIP9, is a protein that in humans is encoded by the NFKBIB gene. The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. This gene is mapped to 19q13.2. It has been found that in vivo, NFKBIB serves both to inhibit and to facilitate the inflammatory response. NFKBIB degradation releases NF-kappa-B dimers, which upregulate proinflammatory target genes such as TNF-alpha. Surprisingly, absence of NFKBIB results in a dramatic reduction of TNF-alpha in response to lipopolysaccharide, even though activation of NF-kappa-B is normal.

Description:
Rabbit IgG polyclonal antibody for NF-kappa-B inhibitor beta (NFKBIB) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
I kappa B beta antibody, I-kappa-B-beta antibody, IkappaBbeta antibody, IKB beta antibody, IkB-B antibody, IkB-beta antibody, IKBB antibody, IKBB_HUMAN antibody, IkBbeta antibody, NF kappa BIB antibody, NF-kappa-B inhibitor beta antibody, NF-kappa-BIB antibody, Nfkbib antibody, Thyroid receptor interacting protein 9 antibody, Thyroid receptor-interacting protein 9 antibody, TR interacting protein 9 antibody, TR-interacting protein 9 antibody, TRIP-9 antibody, TRIP9 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human IKB beta recombinant protein (Position: E56-E237). Human IKB beta shares 82% and 80% amino acid (aa) sequence identity with mouse and rat IKB beta, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.