IkB-ε (phospho-S22) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4107
Background:
IkB-ε (I-kappa-B-epsilon), also known as NFKBIE (NFκB inhibitor epsilon) or IKBE, is a 500 amino acid protein that belongs to the NFκB inhibitor family. Localizing to the cytoplasm, IkB-ε is highly expressed in spleen, testis and lung, with lower levels of expression found in kidney, pancreas, heart, placenta, brain, granulocytes and macrophages. IkB-ε inhibits c-Rel and NFκB subunits p50, p52 and p65 by forming a complex with them in the cytoplasm, preventing them from activating genes in the nucleus. IkB-ε undergoes serine phosphorylation, resulting in the protein being marked for destruction via the ubiquitination pathway.
Alternative Name:
NF-kappa-BIE, I-kappa-B-epsilon, IkB-E, IkB-epsilon, IkappaBepsilon, NFKBIE, IKBE, IkB ε, IkBε
Application Dilution: IHC:1:50~1:200
Specificity: p-IkB-ε (S22) polyclonal antibody detects endogenous levels of IkB-ε protein only when phosphorylated at Ser22
Immunogen:
Synthetic phosphopeptide derived from human IkB-ε around the phosphorylation site of Serine 22.
MW: ~ 45 kDa
Swis Prot.: O00221
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
IkB-ε (I-kappa-B-epsilon), also known as NFKBIE (NFκB inhibitor epsilon) or IKBE, is a 500 amino acid protein that belongs to the NFκB inhibitor family. Localizing to the cytoplasm, IkB-ε is highly expressed in spleen, testis and lung, with lower levels of expression found in kidney, pancreas, heart, placenta, brain, granulocytes and macrophages. IkB-ε inhibits c-Rel and NFκB subunits p50, p52 and p65 by forming a complex with them in the cytoplasm, preventing them from activating genes in the nucleus. IkB-ε undergoes serine phosphorylation, resulting in the protein being marked for destruction via the ubiquitination pathway.
Alternative Name:
NF-kappa-BIE, I-kappa-B-epsilon, IkB-E, IkB-epsilon, IkappaBepsilon, NFKBIE, IKBE, IkB ε, IkBε
Application Dilution: IHC:1:50~1:200
Specificity: p-IkB-ε (S22) polyclonal antibody detects endogenous levels of IkB-ε protein only when phosphorylated at Ser22
Immunogen:
Synthetic phosphopeptide derived from human IkB-ε around the phosphorylation site of Serine 22.
MW: ~ 45 kDa
Swis Prot.: O00221
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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