IKBIP Polyclonal Antibody

Background:
IKIP (Inhibitor of nuclear factor kappa-B kinase-interacting protein, IKK-interacting protein) is a single-pass membrane protein that shares a common promoter with APAF1. APAF1 and IKIP are both induced by X irradiation, however, the two gene products are transcribed in different directions. The IKIP gene is believed to be a target for p53 as expression of IKIP has been shown to promote apoptosis. IKIP has four known isoforms, three of which are found traversing the endoplasmic reticulum membrane. IKIP isoform 4 has a deletion of the transmembrane region which leads to a homogenous distribution of the protein within the cell. The IKIP gene products are expressed in vascular endothelial cells, while the isoform 4 has also been detected in lung, kidney, spleen, thymus and skeletal muscle.

Research Area: Cancer, Cell Biology

Synonyms:
FLJ31051, I kappa B kinase interacting protein, IKBIP, IKBKB interacting protein, IKIP1, IKIP2, IKIP3, IKK interacting protein, Inhibitor of nuclear factor kappa B kinase interacting protein

Immunogen: Recombinant protein of human IKBIP

Swissprot: Q70UQ0
Gene Accession: BC058933

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.