IKK alpha polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
IKKA, also known as conserved helix-loop-helix ubiquitous kinase (CHUK) or IKBKA, is a protein kinase that in humans is encoded by the CHUK gene. It is mapped to 10q24.31. This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. IKKA is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. However, IKKA also has many additional cellular targets, and is thought to function independently of the NF-κB pathway to regulate epidermal differentiation.

Description:
Rabbit IgG polyclonal antibody for Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
chuk antibody, CHUK1 antibody, Conserved Helix Loop Helix Ubiquitous Kinase antibody, Conserved helix loop ubiquitous kinase antibody, Conserved helix-loop-helix ubiquitous kinase antibody, I Kappa B Kinase 1 antibody, I Kappa B Kinase Alpha antibody, I-kappa-B kinase 1 antibody, I-kappa-B kinase alpha antibody, IkappaB kinase antibody, IkB kinase alpha subunit antibody, IKBKA antibody, IKK 1 antibody, IKK A antibody, IKK a kinase antibody, IKK-A antibody, IKK-alpha antibody, IKK1 antibody, IKKA antibody, IKKA_HUMAN antibody, Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells antibody, Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit antibody, Inhibitor of nuclear factor kappa-B kinase subunit alpha antibody, NFKBIKA antibody, Nuclear Factor Kappa B Inhibitor Kinase Alpha antibody, Nuclear factor NF kappa B inhibitor kinase alpha antibody, Nuclear factor NF-kappa-B inhibitor kinase alpha antibody, Nuclear factor NFkappaB inhibitor kinase alpha antibody, Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor antibody, TCF-16 antibody, TCF16 antibody, Transcription factor 16 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human IKK alpha recombinant protein (Position: V411-E745). Human IKK alpha shares 98% amino acid (aa) sequence identity with mouse IKK alpha.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.