IKKγ polyclonal, anti-human, mouse, rat

Background:
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response, this function requires 'Lys-27'-linked polyubiquitination.

Alternative Name:
NEMO, IKKAP1, I-kappa-B kinase subunit gamma, IKK-gamma, IKKG, IkB kinase subunit gamma, IKBKG, FIP3, NEMO, IkB kinase associated protein 1, IkB kinase subunit gamma, Inhibitor of nuclear factor kappa B kinase subunit gamma, AMCBX1, FIP 3, FIP-3, FIP3, Fip3p, I kappa B kinase gamma, I-kappa-B kinase subunit gamma, IkB kinase gamma subunit, IkB kinase subunit gamma, IkB kinase-associated protein 1, Ikbkg, IKK-gamma, IKKAP1, IKKG, IMD33, Incontinentia pigmenti, Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase gamma, Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase of, gamma, Inhibitor of nuclear factor kappa-B kinase subunit gamma, IP, IP1, IP2, IPD2, NEMO, NEMO, NF kappa B essential modifier, NF kappa B essential modulator, NF-kappa-B essential modifier, NF-kappa-B essential modulator, ZC2HC9,

Application Dilution:
WB:1:500-1:2,000
ICC:1:50-1:200
IHC:1:20-1:50
FC:1:50-1:100

Specificity: IKKγ polyclonal antibody detects endogenous levels of IKKγ protein.

Immunogen:
recombinant protein

MW: 48 kDa

Swiss-Prot: Q9Y6K9(Human) O88522(Mouse) Q6TMG5(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.