IKZF2 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61657
Background:
Helios (Ikaros family zinc finger 2, IZKF2) is an Ikaros family transcription factor composed of several zinc fingers that mediate DNA binding and homodimerization or heterodimerization with other Ikaros family proteins. In the hematopoietic system, Helios expression is restricted to T cells and early hematopoietic progenitors. In regulatory T cells, expression of Helios contributes to an anergic phenotype by binding to the IL-2 promoter and suppressing IL-2 transcription. In addition, alteration of the corresponding Helios gene IZKF2 is one hallmark of low-hypodiploid acute lymphoblastic leukemia.
Alternative Name:
Zinc finger protein Helios, Ikaros family zinc finger protein 2, IKZF2, HELIOS, ZNFN1A2
Application Dilution: WB: 1:500~1:1000
Specificity: IKZF2 polyclonal antibody detects endogenous levels of IKZF2 protein.
Immunogen:
Synthetic peptide, corresponding Human IKZF2.
MW: ~ 85 kDa
Swis Prot.: Q9UKS7
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Helios (Ikaros family zinc finger 2, IZKF2) is an Ikaros family transcription factor composed of several zinc fingers that mediate DNA binding and homodimerization or heterodimerization with other Ikaros family proteins. In the hematopoietic system, Helios expression is restricted to T cells and early hematopoietic progenitors. In regulatory T cells, expression of Helios contributes to an anergic phenotype by binding to the IL-2 promoter and suppressing IL-2 transcription. In addition, alteration of the corresponding Helios gene IZKF2 is one hallmark of low-hypodiploid acute lymphoblastic leukemia.
Alternative Name:
Zinc finger protein Helios, Ikaros family zinc finger protein 2, IKZF2, HELIOS, ZNFN1A2
Application Dilution: WB: 1:500~1:1000
Specificity: IKZF2 polyclonal antibody detects endogenous levels of IKZF2 protein.
Immunogen:
Synthetic peptide, corresponding Human IKZF2.
MW: ~ 85 kDa
Swis Prot.: Q9UKS7
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
| Is Featured? | No |
|---|
Write Your Own Review