IKZF3 Polyclonal Antibody

Background:
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
AIO, Aiolos, IKAROS family zinc finger 3 (Aiolos), IKAROS family zinc finger 3, Ikaros family zinc finger protein 3, IKZF 3, IKZF3, IKZF3, zinc finger DNA binding protein Aiolos, Zinc finger protein Aiolos, Zinc finger protein subfamily 1A 3 (Aiolos), Zinc finger protein subfamily 1A 3, Zinc finger protein subfamily 1A, member 3, ZNFN1A3

Immunogen: Recombinant protein of human IKZF3

Swissprot: Q9UKT9
Gene Accession: BC032707

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.7 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-101982