IL-16 (clone J2F10), anti-human, mouse

Decription:
Interleukin-16 (IL-16) is an immunomodulatory cytokine, which induces lymphocyte migration, expression of proinflammatory IL-1beta, IL6 and tumour necrosis factor-alpha (TNFalpha), and modulates apoptosis. This protein is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. Also, IL-16 has been shown to recruit and activate many other cell including monocytes, eosinophils, and dendritic cells expressing the CD4 molecules.

Synonyms: LCF, prIL-16, FLJ16806, FLJ42735, FLJ44234, HST19289, IL 16, Lymphocyte chemoattractant factor, HGNC:5980, Interleukin 16 precursor, PrIL16,

Clone: J2F10. Anti-human IL-16 mAb, clone J2F10, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human IL-16 protein.

Isotype: Mouse IgG1, k

Immunogen: Recombinant human IL-16 (502-631aa) purified from E. coli

Reactivity: human, mouse

Form: Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

Applications: ELISA, WB (Cell lysate)

Working Dilution: Optimal dilution should be performed by user.

NCBI Nr.: NP_004504

Concentration: 0.1 mg/ml

Storage: Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.

References:
Bernstein HB., et al. (2006) J Immunol. 15; 177(6):3669-76.
McFadden C J., et al. (2007) J Immunol. 15; 179(10):6439-45.
Cruikshank WW, et al. (2000) J Leukoc Biol 67:757-66.
Center DM, et al. (2000) Immunol Today. (6):273-80.