Presenilin 2 (phospho Ser330) polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP67956
Background:
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion- endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369).
Other Names:
PSEN2; AD4; PS2; PSNL2; STM2; Presenilin-2; PS-2; AD3LP; AD5; E5-1; STM-2
Antigen Type: synthetic peptide
Antigen Type: PSEN2
Gene ID: 5664
Primary Accession: P49810
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion- endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369).
Other Names:
PSEN2; AD4; PS2; PSNL2; STM2; Presenilin-2; PS-2; AD3LP; AD5; E5-1; STM-2
Antigen Type: synthetic peptide
Antigen Type: PSEN2
Gene ID: 5664
Primary Accession: P49810
| Is Featured? | No |
|---|
Write Your Own Review