IL-1alpha (clone Bamboo-1), anti-mouse

Decription:
The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.

Synonyms: Interleukin-1alpha

Clone: Bamboo-1

Isotype: Mouse IgG

Immunogen: Recombinant mouse mature IL-1alpha.

Reactivity: mouse

Specificity: Recognizes mouse IL-1alpha.

Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.

Applications:
Western Blot: (1?g/ml)
ELISA

Working Dilution: Optimal conditions must be determined individually for each application.

Concentration: 1mg/ml