IL-23 polyclonal, anti-human, mouse, rat

Protein Family: Cytokines

Pathway and Disease: Signal Transduction, Immune System

Description:
Interleukin-23 (IL-23) is a heterodimer cytokine composed of IL-23-alpha and IL12B. IL-23 functions in innate and adaptive immunity. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and has been implicated in autoimmune inflammatory diseases and tumorigenesis.

Alternate Names: Interleukin-23 subunit alpha, IL-23 subunit alpha, IL-23-A, Interleukin-23 subunit p19, IL-23p19, IL-23, IL23A, SGRF

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: Q9NPF7

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IL-23.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.