IL-31Rα rabbit polyclonal, anti-human, mouse, rat

Backgroud: The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011],function:Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity.,induction:Up-regulated in lesional keratinocytes of patients with atopic dermatitis. Up-regulated by IFNG and lipopolysaccharides.,PTM:N-glycosylated.,similarity:Belongs to the type I cytokine receptor family. Type 2 subfamily.,similarity:Contains 5 fibronectin type-III domains.,subunit:Heterodimer with OSMR. Interacts with JAK1 and STAT3.,tissue specificity:Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin. Detected in all of the myelomonocytic lineage. Expressed in CD14-and CD56-positive blood cells and by macrophages (at protein level).,

Synonyms: IL31RA, CRL3, GPL, Interleukin-31 receptor subunit alpha, IL-31 receptor subunit alpha, IL-31R subunit alpha, IL-31R-alpha, IL-31RA, Cytokine receptor-like 3, GLM-R, hGLM-R, Gp130-like monocyte receptor, Gp130-like receptor, ZcytoR17

Gene Name: IL31RA

Gene ID: 133396

SwissProt ID: Q8NI17

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.