IL-4 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5764
Background:
Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNFβ and IFN-γ, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2, and IgG3.
Alternative Name:
Interleukin-4, Interleukin 4, Interleukin4, B-cell stimulatory factor 1, BSF-1, BSF1, Binetrakin, Lymphocyte stimulatory factor 1, Pitrakinra, IL4
Application Dilution: WB: 1:500~1:1000
Specificity: IL-4 polyclonal antibody detects endogenous levels of IL-4 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 108-153 of Human IL-4.
MW: ~ 18 kDa
Swis Prot.: P05112
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNFβ and IFN-γ, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2, and IgG3.
Alternative Name:
Interleukin-4, Interleukin 4, Interleukin4, B-cell stimulatory factor 1, BSF-1, BSF1, Binetrakin, Lymphocyte stimulatory factor 1, Pitrakinra, IL4
Application Dilution: WB: 1:500~1:1000
Specificity: IL-4 polyclonal antibody detects endogenous levels of IL-4 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 108-153 of Human IL-4.
MW: ~ 18 kDa
Swis Prot.: P05112
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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