IL10 antibody (clone 1C10), anti-human

Background:
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.

Other Names:
Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF, IL10

Antigen Type:
Recombinant Protein

Gene Name: IL10
Gene ID: 3586
NCBI Accession: NP_000563.1
Primary Accession: P22301
Other Accession: NM_000572
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .