IL10 polyclonal, anti-human

Background:
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Synonyms: CSIF, IL 10, IL-10, IL10A, interleukin 10, TGIF

Cellular Location: Secreted

Immunogen:
Recombinant protein of human IL10

Gene Symbol: IL10

Gene ID: 3586

Swiss prot: P22301

Calculated MW: 21kDa

Recommended dilution:
WB 1:5000-8000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.