IL10RA Polyclonal Antibody

Background:
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.

Research Area: Cancer, Immunology

Synonyms:
CD210, CDw210a, CDw210a antigen, HIL 10R, HIL10R, I10R1, IL 10R 1, IL 10R A, IL 10R, IL 10R1, IL-10 receptor subunit alpha, IL-10R subunit 1, IL-10R subunit alpha, IL-10R1, IL-10RA, IL10R, IL10R1, IL10RA, Interleukin 10 receptor alpha, Interleukin 10 receptor alpha chain, Interleukin-10 receptor subunit 1, Interleukin-10 receptor subunit alpha

Immunogen: Recombinant protein of human IL10RA

Swissprot: Q13651
Gene Accession: BC028082

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-986/sc-984/sc-25477/sc-985