IL12 polyclonal, anti-human, mouse, rat

Background:
IL-12 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.

Synonyms: IL-12A, CLMF p35, IL-12 subunit p35, NKSF1, IL12A

Cellular Location: Cell membrane Secreted

Immunogen:
A synthetic peptide of human IL12

Gene Symbol: IL12

Gene ID: 3592

Swiss prot: P29459

Calculated MW: 52kDa

Recommended dilution:
WB 1:3000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.