IL12RB1 polyclonal, anti-human, mouse

Background:
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.

Synonyms: CD212, IL-12R-BETA1, IL12RB, IMD30

Cellular Location: Membrane Single-pass type I membrane protein

Immunogen:
Recombinant protein of human IL12RB1

Gene Symbol: IL12RB1

Gene ID: 3594

Swiss prot: P42701

Calculated MW: 73kDa

Recommended dilution:
WB 1:500-2000, IF 1:10-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.