IL15 antibody (clone 3A3), anti-human
€435.00
In stock
SKU
AC-AT2505a
Catalog Number: AC-AT2505a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: E
Request Information AC-AT2505a">Request Information
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: E
Request Information AC-AT2505a">Request Information
Background:
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq]
Other Names:
Interleukin-15, IL-15, IL15
Antigen Type:
Recombinant Protein
Gene Name: IL15
Gene ID: 3600
NCBI Accession: NP_000576.1;NP_751915.1
Primary Accession: P40933
Other Accession: NM_000585
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq]
Other Names:
Interleukin-15, IL-15, IL15
Antigen Type:
Recombinant Protein
Gene Name: IL15
Gene ID: 3600
NCBI Accession: NP_000576.1;NP_751915.1
Primary Accession: P40933
Other Accession: NM_000585
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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