IL17RA Polyclonal Antibody

Background:
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research Area: Cancer, Immunology

Synonyms:
CANDF5, CD217, CD217 antigen, CDw217, CTLA8, HIL 17R, hIL17R, I17RA, IL 17 receptor A, IL 17 receptor, IL 17RA, IL-17 receptor A, IL-17RA, IL17, IL17A receptor, IL17R, IL17RA, IMD51, Interleukin 17 receptor A, Interleukin-17 receptor A, MGC10262

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse IL17RA

Swissprot: Q96F46,Q60943

Calculated MW: 96 kDa
Observed MW: 96 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 0.96 mg/mL
Dilution: WB 1:500-1:1000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.