IL18 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS6823
Background:
Four structurally related IL-1 receptor ligands have been described. These include three agonists designated IL-1α, IL-1β and IL-1γ/IL-18 and a specific receptor antagonist, IL-1Rα. IL-1α and IL-1β play critical roles in the regulation of the immune response and inflammation, serving as activators of T and B lymphocytes and NK (natural killer) cells. IL-18 (also referred to as IL-1γ) has been shown to augment the secretion of IFN-γ from T lymphocytes and increase NK cell activity in spleen cells. IL-18 exhibits 19% and 12% identity with IL-1α and IL-1β respectively over the 12 β-strands of the β-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1β pro-domain which must be cleaved by the serine protease ICE for optimal secretion and biological activity. Originally described as IGIF (IFN-γ-inducing factor), IL-18 is induced by mouse liver subsequent to challenge with lipopolysaccharide (LPS).
Alternative Name:
IL18, IGIF, IL-18, IL-1g, IL1F4, MGC12320,
Application Dilution: WB: 1:500 - 1:2000, IP 1:50 - 1:100
Specificity: IL18 polyclonal antibody detects endogenous levels of IL18 protein.
Immunogen:
Recombinant full length Human IL18.
MW: ~ 23 kDa
Swis Prot.: Q14116
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Four structurally related IL-1 receptor ligands have been described. These include three agonists designated IL-1α, IL-1β and IL-1γ/IL-18 and a specific receptor antagonist, IL-1Rα. IL-1α and IL-1β play critical roles in the regulation of the immune response and inflammation, serving as activators of T and B lymphocytes and NK (natural killer) cells. IL-18 (also referred to as IL-1γ) has been shown to augment the secretion of IFN-γ from T lymphocytes and increase NK cell activity in spleen cells. IL-18 exhibits 19% and 12% identity with IL-1α and IL-1β respectively over the 12 β-strands of the β-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1β pro-domain which must be cleaved by the serine protease ICE for optimal secretion and biological activity. Originally described as IGIF (IFN-γ-inducing factor), IL-18 is induced by mouse liver subsequent to challenge with lipopolysaccharide (LPS).
Alternative Name:
IL18, IGIF, IL-18, IL-1g, IL1F4, MGC12320,
Application Dilution: WB: 1:500 - 1:2000, IP 1:50 - 1:100
Specificity: IL18 polyclonal antibody detects endogenous levels of IL18 protein.
Immunogen:
Recombinant full length Human IL18.
MW: ~ 23 kDa
Swis Prot.: Q14116
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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