IL1R2 polyclonal antibody, anti-human, mouse, rat

Background:
Non-signaling receptor for IL1A, IL1B and IL1RN. ReducesIL1B activities. Serves as a decoy receptor by competetive bindingto IL1B and preventing its binding to IL1R1. Also modulatescellular response through non-signaling association with IL1RAPafter binding to IL1B. IL1R2 (membrane and secreted forms)preferentially binds IL1B and poorly IL1A and IL1RN. The secretedIL1R2 recruits secreted IL1RAP with high affinity, this complexformation may be the dominant mechanism for neutralization of IL1Bby secreted/soluble receptors.

Alternative Name:
Interleukin-1 receptor type 2, IL-1R-2, IL-1RT-2, IL-1RT2, CD121 antigen-like family member B, CDw121b, IL-1 type II receptor, Interleukin-1 receptor beta, IL-1R-beta, Interleukin-1 receptor type II, CD121b, mIL-1R2, mIL-1RII, sIL-1R2, sIL-1RII, IL1R2, IL1RB

Application Dilution:
WB: 1:500~1:1000

Specificity: IL1R2 polyclonal antibody detects endogenous levels of IL1R2 protein.

Immunogen:
Synthetic peptide, corresponding to Human IL1R2

MW: ~ 45 kDa

Swiss-Prot: P27930

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.