IL1RL1 polyclonal, anti-human, mouse

Protein Family: Receptors and Channels

Pathway and Disease: Immune System, Signaling Molecules and Interaction

Description:
Interleukin-1 receptor-like 1 (IL1RL1, ST2, IL-33R) is a member of a superfamily containing the interleukin-1 receptor and the Toll-like receptors (TLRs). The TLRs are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. IL1RL1 was originally identified as a protein whose production was stimulated by various proliferation-inducing agents such as PDGF and FGF. More recently, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor (TLR) 4 signaling and to maintain endotoxin tolerance. It has been suggested that the inhibition of TLR4 signaling occurs through the association and sequestering of TLR adaptor molecules such as MyD88 and TIRAP.

Alternate Names: ST2, IL1RL1, Interleukin-1 receptor-like 1, Protein ST2, DER4, T1, IL33 receptor, IL-33 receptor, IL33R, IL-33R

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: Q01638

Antigen: Recombinant human IL1RL1

Format: Each vial contains 0.1 ml IgG (1 mg/ml) in PBS pH 7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.