IL2 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60299
Background:
Lymphokines are a group of signaling molecules involved in communication between cells of the immune system. Lymphokines secreted by activated lymphocytes include proteins such as IL-2. This protein is secreted primarily by helper T cells that have been activated through the T cell receptor complex or by other mitogens. Cells targeted by IL-2 include activated T helper and cytotoxic T cells, inducing their proliferation. The secretion of IL-2 can also act as a growth factor for B cells. To date, three different IL-2-dependent signal transduction pathways have been identified: the c-Fos/c-Jun induction pathway mediated by Src family protein-tyrosine kinases; the c-Myc induction pathway; and the Rapamycin-sensitive pathway; all of which result in the induction of Bcl-2. In addition, the transcription factor NFAT has been shown to play a major role in the regulation of IL-2 transcription and correlates to an age-related decline in the expression of IL-2.
Alternative Name:
Interleukin-2, IL-2, T-cell growth factor, TCGF, INN=Aldesleukin, IL2
Application Dilution: WB: 1:500~1:1000
Specificity: IL2 polyclonal antibody detects endogenous levels of IL2 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human IL2.
MW: ~ 18 kDa
Swis Prot.: P60568
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Lymphokines are a group of signaling molecules involved in communication between cells of the immune system. Lymphokines secreted by activated lymphocytes include proteins such as IL-2. This protein is secreted primarily by helper T cells that have been activated through the T cell receptor complex or by other mitogens. Cells targeted by IL-2 include activated T helper and cytotoxic T cells, inducing their proliferation. The secretion of IL-2 can also act as a growth factor for B cells. To date, three different IL-2-dependent signal transduction pathways have been identified: the c-Fos/c-Jun induction pathway mediated by Src family protein-tyrosine kinases; the c-Myc induction pathway; and the Rapamycin-sensitive pathway; all of which result in the induction of Bcl-2. In addition, the transcription factor NFAT has been shown to play a major role in the regulation of IL-2 transcription and correlates to an age-related decline in the expression of IL-2.
Alternative Name:
Interleukin-2, IL-2, T-cell growth factor, TCGF, INN=Aldesleukin, IL2
Application Dilution: WB: 1:500~1:1000
Specificity: IL2 polyclonal antibody detects endogenous levels of IL2 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human IL2.
MW: ~ 18 kDa
Swis Prot.: P60568
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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