IL24 Polyclonal Antibody

Background:
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported.IL24 (Interleukin 24) is a Protein Coding gene. Diseases associated with IL24 include Melanoma and Subclavian Steal Syndrome. Among its related pathways are PEDF Induced Signaling and Immune response IL-23 signaling pathway. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL20.

Research Area: Cancer, Immunology

Synonyms:
C49A, FISP, IL 24, IL 4 induced secreted protein, IL-24, IL10B, Il24, IL24, interleukin 24, Interleukin-24, MDA-7, MDA7, Melanocyte associated Mda 7, Melanoma differentiation association protein 7, Melanoma differentiation-associated gene 7 protein, Mob5, ST16, Suppression of tumorigenicity 16 (melanoma differentiation), Suppression of tumorigenicity 16, Suppression of tumorigenicity 16 protein

Immunogen: Synthetic peptide of human IL24

Swissprot: Q13007
Gene Accession: NP006841

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.78 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.