IL27 Polyclonal Antibody

Background:
IL-27,a member of IL-12/IL-23 heterodimeric family of cytokines,has pleiotropic properties that can enhance or limit immune responses. IL-27 is a heterodimeric cytokine composed of two subunits: IL-27a and IL-27b. IL-27 acts on various cell types,including T cells,B cells,macrophages,dendritic cells,natural killer (NK) cells and non-hematopoietic cells. IL-27 plays a critical role in the early regulation of T helper type 1 initiation,and enhances proliferation of naive CD4+T cells and naive B cells. It,however,also exerts anti-inflammatory functions by inhibiting the development of Th17 cells and inducing IL-10 producing type 1 regulatory T cells. IL-27 is a potentially promising cytokine for therapeutic approaches on various human diseases.

Research Area: Cancer, Immunology

Synonyms:
EBI3, IL 27, IL 27 p28 subunit, IL 27A, IL 30, IL-27 subunit alpha, IL-27-A, IL27, IL27-A, IL27A, IL27A_HUMAN, IL27p28, IL30, Interleukin 27, Interleukin 27 subunit alpha

Immunogen: Recombinant Human Interleukin-27 subunit alpha protien

Swissprot: Q8NEV9

Purification Method: Affinity purification

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Concentration: 2 mg/mL
Dilution: IHC 1:100-1:400

Storage:
Store at -20°C. Avoid freeze / thaw cycles.