IL31RA polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS7934
Background:
IL-31 is a T cell cytokine that is preferentially produced by T helper type 2 cells. IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM). This receptor complex recruits JAK1, JAK2, Stat1, Stat3 and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD). Comparisons between skin from patients with AD and healthy skin showed IL-31R expression at higher levels on epidermal keratinocytes in AD samples. Infiltrating cells, more numerous in skin from patients with AD compared with that of healthy individuals, expressed IL-31 mRNA. IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis, and may represent a novel target for antipruritic drug development.
Alternative Name:
Class I cytokine receptor, CRL 3, CRL, CRL3, Cytokine receptor like 3, Cytokine receptor-like 3, GLM R, GLM-R, GLMR, Gp130 like monocyte receptor, GP130 like receptor, Gp130-like monocyte receptor, Gp130-like receptor, GPL, HGLM R, HGLM-R, HGLMR, IL 31 receptor subunit alpha, IL 31R subunit alpha, IL 31RA, IL-31 receptor subunit alpha, IL-31R subunit alpha, IL-31R-alpha, IL-31RA, IL31 receptor subunit alpha, IL31R subunit alpha, IL31R_HUMAN, IL31RA, Interleukin 31 receptor A, interleukin 31 receptor subunit alpha, Interleukin-31 receptor subunit alpha, MGC125346, PLCA 2, PLCA2, PRO21384, Soluble type I cytokine receptor CRL3, ZcytoR17,
Application Dilution: WB: 1:500 - 1:2000
Specificity: IL31RA polyclonal antibody detects endogenous levels of IL31RA protein.
Immunogen:
Recombinant full length Human IL31RA.
MW: ~ 83 kDa
Swis Prot.: Q8NI17
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
IL-31 is a T cell cytokine that is preferentially produced by T helper type 2 cells. IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM). This receptor complex recruits JAK1, JAK2, Stat1, Stat3 and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD). Comparisons between skin from patients with AD and healthy skin showed IL-31R expression at higher levels on epidermal keratinocytes in AD samples. Infiltrating cells, more numerous in skin from patients with AD compared with that of healthy individuals, expressed IL-31 mRNA. IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis, and may represent a novel target for antipruritic drug development.
Alternative Name:
Class I cytokine receptor, CRL 3, CRL, CRL3, Cytokine receptor like 3, Cytokine receptor-like 3, GLM R, GLM-R, GLMR, Gp130 like monocyte receptor, GP130 like receptor, Gp130-like monocyte receptor, Gp130-like receptor, GPL, HGLM R, HGLM-R, HGLMR, IL 31 receptor subunit alpha, IL 31R subunit alpha, IL 31RA, IL-31 receptor subunit alpha, IL-31R subunit alpha, IL-31R-alpha, IL-31RA, IL31 receptor subunit alpha, IL31R subunit alpha, IL31R_HUMAN, IL31RA, Interleukin 31 receptor A, interleukin 31 receptor subunit alpha, Interleukin-31 receptor subunit alpha, MGC125346, PLCA 2, PLCA2, PRO21384, Soluble type I cytokine receptor CRL3, ZcytoR17,
Application Dilution: WB: 1:500 - 1:2000
Specificity: IL31RA polyclonal antibody detects endogenous levels of IL31RA protein.
Immunogen:
Recombinant full length Human IL31RA.
MW: ~ 83 kDa
Swis Prot.: Q8NI17
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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