IL3RA Polyclonal Antibody

Background:
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.

Research Area: Cancer, Immunology, Signal transduction

Synonyms:
IL3RA, CD123, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra

Immunogen: A synthetic peptide of human IL3RA (NP_002174.1).

Swissprot: P26951
Gene ID: 3563

Calculated MW: 34 kDa/43 kDa
Observed MW: 70 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:100-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.