IL5RA Polyclonal Antibody

Background:
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported.

Research Area: Immunology

Synonyms:
CD125, CD125 antigen, CDw125, HSIL5R3, IL-5 receptor subunit alpha, IL-5R subunit alpha, IL-5R-alpha, IL-5RA, IL5R, IL5RA, IL5RA, Interleukin 5 Receptor alpha, Interleukin 5 Receptor alpha chain, Interleukin 5 receptor alpha subunit, Interleukin 5 receptor subunit alpha, Interleukin 5 receptor type 3, Interleukin-5 receptor subunit alpha, MGC26560

Immunogen: Synthetic peptide of human IL5RA

Swissprot: Q01344
Gene Accession: NP_000555

Calculated MW: 48 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.9 mg/mL
Dilution: WB 1:200-1:1000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-21904/sc-30009/sc-673