ILF3 Polyclonal Antibody

Background:
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms:
CBTF, Double stranded RNA binding protein 76, Double-stranded RNA-binding protein 76, DRBF, DRBP76, ILF3, ILF3, Interleukin enhancer binding factor 3, Interleukin enhancer-binding factor 3, M phase phosphoprotein 4, M-phase phosphoprotein 4, MPHOSPH4, MPP4, NF AT 90, NF-AT-90, NF110, NF90, NFAR, Nuclear factor associated with dsRNA, Nuclear factor of activated T cells 90 kDa, Nuclear factor of activated T-cells 90 kDa, TCP80, Translational control protein 80

Immunogen: Fusion protein of human ILF3

Swissprot: Q12906
Gene Accession: BC064836

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.72 mg/mL
Dilution: IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.