IMPA1 Polyclonal Antibody

Background:
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1, 4, 5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1, 3-diphosphate, myo-inositol-1, 4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

Research Area: Cancer, Metabolism, Neuroscience, Signal transduction

Synonyms:
IMP 1, IMP, IMPA 1, IMPA, IMPA1, IMPA1, IMPase 1, IMPase, Inositol 1(or 4) monophosphatase, Inositol monophosphatase 1, Inositol monophosphatase, Inositol(myo) 1(or 4) monophosphatase 1, Inositol-1(or 4)-monophosphatase 1, Lithium sensitive myo inositol monophosphatase A1, Lithium-sensitive myo-inositol monophosphatase A1

Immunogen: Fusion protein of human IMPA1

Swissprot: P29218
Gene Accession: BC009565

Calculated MW: 30 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.9 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.