ING4 Blocking Peptide (C-term)

Background:
Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).

Other Names:
Inhibitor of growth protein 4, p29ING4, ING4

Target/Specificity:
The synthetic peptide sequence is selected from aa 182-195 of HUMAN ING4

Gene Name: ING4

Gene ID: 51147
Primary Accession: Q9UNL4
Other Accession: Q9D8Y8; Q8WYH8; Q8C0D7; Q5ZKY4; Q3T095
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.